White Centered hemorrhages
𝗥𝗼𝘁𝗵 𝗦𝗽𝗼𝘁𝘀
Described by Moritz Roth in 1872, Named as ‘Roth Spot’ in 1878 by Litten
𝘌𝘵𝘪𝘰𝘭𝘰𝘨𝘪𝘦𝘴:
● Subacute bacterial endocarditiis
● Anemia/Thrombocytopenia
● Leukemia
● Collagen vascular diseases
● Hypertensive/Diabetic Retinopathy
● HIV
● Anoxia
● Shaken baby syndrome
● CO poisoning
● Vitamin B 12 deficiency
● Traumatic delivery etc
𝘗𝘢𝘵𝘩𝘰𝘱𝘩𝘺𝘴𝘪𝘰𝘭𝘰𝘨𝘺:
● They result from retinal capillary rupture and extrusion of whole blood.
● This is followed by platelet adhesion to the damaged endothelium initiating a
coagulation cascade and formation of a white lesion in the centre of the hemorrhage,
which is a platelet-fibrin thrombus.
● In leukemia, the white centre could correspond to an accumulation of leukemic cells.
𝘚𝘺𝘮𝘱𝘵𝘰𝘮𝘴:
Asymptomatic unless macula is involved
𝙁𝙞𝙣𝙙𝙞𝙣𝙜 𝙤𝙛 𝙍𝙤𝙩𝙝 𝙎𝙥𝙤𝙩𝙨 𝙨𝙝𝙤𝙪𝙡𝙙 𝙙𝙞𝙧𝙚𝙘𝙩 𝙩𝙝𝙚 𝙤𝙥𝙝𝙩𝙝𝙖𝙡𝙢𝙤𝙡𝙤𝙜𝙞𝙨𝙩 𝙛𝙤𝙧 𝙤𝙩𝙝𝙚𝙧 𝙥𝙝𝙮𝙨𝙞𝙘𝙖𝙡 𝙨𝙞𝙜𝙣𝙨 𝙤𝙛 𝙨𝙮𝙨𝙩𝙚𝙢𝙞𝙘 𝙞𝙡𝙡𝙣𝙚𝙨𝙨𝙚𝙨 𝙖𝙨𝙨𝙤𝙘𝙞𝙖𝙩𝙚𝙙 𝙬𝙞𝙩𝙝 𝙍𝙤𝙩𝙝 𝙎𝙥𝙤𝙩𝙨
𝙏𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩 𝙨𝙝𝙤𝙪𝙡𝙙 𝙗𝙚 𝙙𝙞𝙧𝙚𝙘𝙩𝙚𝙙 𝙖𝙩 𝙪𝙣𝙙𝙚𝙧𝙡𝙮𝙞𝙣𝙜 𝙨𝙮𝙨𝙩𝙚𝙢𝙞𝙘 𝙞𝙡𝙡𝙣𝙚𝙨𝙨
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