Meibomian Cyst!

Chalazion/ Meibomian Cyst!

-Gradually enlarging painless nodule.

PATHOPHYSIOLOGY:

-Meibomian gland secretions → blocked → retained oily secretions → breakdown of lipid possibly from bacterial enzymes or retained meibomian secretions → leak into adjacent tissue (surrounding tarsal plate stroma) → Chronic granulomatous inflammation of multinucleated giant cells and epithelioid cells surrounding a lipid globule (Lipogranuloma).

RISK FACTORS:

•Blepharitis

•Rosacea

•Seborrheic dermatitis

•Demodex mite infestation

•Low serum Vitamin A

•GI inflammation

•Smoking

•Diabetes

HISTOPATHOLOGY:

•Lipogranulomatous with extracellular fat deposits, epitheloid cells, multinucleated giant cells and lymphocytes.

ATYPICAL CHALAZIA:

•Do a biopsy to rule out neoplasms, infection (leishmaniasis/ TB masses), immune disorders (hyper IgE syndrome).

MANAGEMENT:

•Warm compress.

•Lid massage (to express the contents).

•Good lid hygiene.

•Oral Antibiotics (for significant bacterial infections).

•Intralesional injection of Triamcinalone.

•Incision & Curettage.

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